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. 2019 Mar 5;9:3521. doi: 10.1038/s41598-019-39724-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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VTA dopamine neuron recordings. (a) Fluorescent signals acquired in VTA from GCaMP6f (green) and tdTomato (red) expressed in dopamine neurons, recorded using the ‘2 colour time division’ acquisition mode. Black triangles indicate times of unpredictable reward delivery. (b) VTA response aligned on reward delivery, line shows mean and shaded area shows standard error. (c) Signals acquired from GCaMP6f expressing dopamine neuron terminals in nucleus accumbens using the ‘1 colour time division’ acquisition mode with 465 nm illumination (green) and 405 nm isosbestic illumination (purple). (d) NAc terminal response aligned on reward delivery.