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. 2019 Mar 5;9:3506. doi: 10.1038/s41598-019-39922-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ex-vivo MRI derived data per region of interest at PCA 32 days. (A) T1-weighted relative volumes normalised to total brain volume with representative image of segmented volume. (B) DTI fractional anisotropy and (C) DTI mean diffusivity data with representative image of DTI acquisition. Data displayed as median and IQR with significance as *0.05 ≥ p > 0.01; ** 0.01 ≥ p > 0.001; ***p < 0.001.