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. 2019 Mar 5;9:3480. doi: 10.1038/s41598-019-39843-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Downregulation of FGFR2 is associated with poor prognosis in prostate cancer. (a) Kaplan-Meier tumor free survival rates of prostate cancer, cervical squamous cell carcinoma, and glioblastoma multiforme were analyzed based on the TCGA data. p-value was calculated by Log-rank Test. (b) The relative FGFR2 mRNA levels were analyzed with data obtained from the following GEO data sets; GSE6919 for prostate cancer, normal adjacent to tumor tissues (n = 59), primary tumor tissues (n = 66), and metastatic tumor tissues (n = 25); GSE9750 for cervical cancer, normal cervix tissues (n = 24) and cervical cancer tissue (n = 28); GSE15824 for glioblastoma, normal brain tissue (n = 5) and brain tumor tissue (n = 30). *** denotes p < 0.001 between the indicated groups. (c) GSEA enrichment plot for CHANDRAN_METASTASIS_UP gene set and PID_HIF1_AND_HIF2_PATHWAY gene set analyzed in prostate cancer.