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. 2019 Mar 5;9:3480. doi: 10.1038/s41598-019-39843-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FGFR2 suppresses the HIF-mediated EMT in prostate cancer cells. DU145 cells were co-transfected with si-FGFR2 (a,c) or FGFR2-FLAG (b,d) with si-HIF-1α and si-HIF-2α, and incubated under normoxic or hypoxic conditions for 24 hours. Cells were subjected to immunoblotting with the indicated antibodies and the blots were quantified by densitometry measurements with ImageJ (right panels). The mRNA levels of CDH1 and TWIST or SNAI2 were quantified by RT-qPCR. All experiments were performed three times and results are expressed as bars representing the means + SD. * and ** denotes p < 0.05 and p < 0.01 between the indicated groups, respectively.