Table 1.
Demographic and clinical features of selected PNH patients.
| Group | Females/Males (F/M) | Age (years) | Treatment other than Eculizumab | Thrombosis (YES/NO)/Arterial/Venous thrombosis (AT/VE) | PNH clone in neutrophils (%) | PNH clone in monocytes (%) | LDH ratio | Direct bilirubin (mg/dL) | Total bilirubin (mg/dL) | Reticulocytes (%) | Hemoglobin (g/dL) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient 1 | No-Ecu | M | 51 | Steroids | NO | 92.2 | 96.9 | 8.05 | 0.7 | 3.0 | <0.5 | 12.3 |
| Patient 2 | No-Ecu | F | 13 | NO | NO | 39.3 | 43.4 | 2.55 | 0.0 | 1.4 | 4 | 12.7 |
| Patient 3 | No-Ecu | F | 65 | Anticoagulants | YES/AT | 97.5 | 96.6 | 4.48 | 0.6 | 1.9 | N.D. | 7.7 |
| Patient 4 | Ecu-Thrombosis | M | 46 | NO | YES/AT | 72.7 | 81.4 | 8.24 | 0.3 | 2.3 | 6.9 | 8.9 |
| Patient 5 | Ecu-Thrombosis | M | 58 | Anticoagulants | YES/VE | 86.5 | 86.7 | 0.74 | 0.6 | 8.5 | N.D. | 12.3 |
| Patient 6 | Ecu-Thrombosis | M | 45 | NO | YES/AT | 99.2 | 97.1 | 0.82 | 0.8 | 2.4 | 4.7 | 11.1 |
| Patient 7 | Ecu-no-Thrombosis | F | 49 | NO | NO | 89.3 | 94.4 | 1.27 | 0.4 | 3.3 | 7.5 | 12.1 |
| Patient 8 | Ecu-no-Thrombosis | M | 63 | NO | NO | 99.4 | 92.8 | 1.51 | N.D. | 1.5 | 9.5 | 11.9 |
| Patient 9 | Ecu-no-Thrombosis | M | 64 | NO | NO | 97.9 | 100 | 2.62 | 0.8 | 1.7 | 9.2 | 10.1 |
N.D. Not Determined. LDH is represented as ratio between the actual value and the upper normal reference level.