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. 2019 Mar 5;9:3525. doi: 10.1038/s41598-019-40203-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evolution of blood B cells in BP patients treated with rituximab. Panel A: Percentage of total CD19+ B cells (Kruskal-Wallis test Dunn’s comparison relative to day 0). Panel B: Number of BP180-specific B cell IgM+ (white bars) or IgG+ (blue bars) in BP patients at day 0, in BP patients in complete remission off therapy (CRoffT) or on minimal therapy (CRMT) at Month 24, and in healthy individuals (HI) (Mann Whitney T-Test).