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. 2019 Feb 1;27(3):542–558. doi: 10.1016/j.ymthe.2019.01.016

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Rescue Experiment with miR-183-5p/Erbin

The expression of Erbin and the phosphorylation levels of RAS/RAF/MEK/ERK and PI3K/AKT/FoxO3a pathways were detected by western blotting analysis in HL-60 (A) and U937 (B) cells after transfection with control vector, miR-183 mimic or miR-183 inhibitor, Lv-Erbin or Lv-shErbin, and miR-183 mimic+Lv-Erbin or miR-183 inhibitor+Lv-shErbin. *p < 0.05 versus control. (C) Tumors were collected from nude mice injected with AML cells transfected with miR-NC, miR-183 mimic or miR-183 inhibitor, Lv-Erbin+miR-NC or Lv-shErbin+miR-NC, and miR-183 mimic+Lv-Erbin or miR-183 inhibitor+Lv-shErbin. The tumor volume was analyzed every 5 days. The tumor weight was measured 30 days after tumor transplantation. *p < 0.05 compared with the NC group.