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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Biol Psychol. 2018 Dec 12;142:1–12. doi: 10.1016/j.biopsycho.2018.12.008

Table 1.

Evidence of neuroinflammation-induced dopamine alterations within corticostriatal brain regions in rodent MIA models of ASD

Dopamine Marker Developmental
Stage		 Sex Region Finding Study
Prenatal LPS Exposure
 DA Peripubertal Male/Female NAcc ↓ (Romero et al., 2010)
 DA Adult Male/Female NAcc ↑ (Romero et al., 2010)
 DA Adult Male Striatum ↓ (Kirsten, Taricano, Flório, et al., 2010)
 DA Adult Female Striatum ↓ (Soto et al., 2013)
 DOPAC Adult Male Striatum ↓ (Kirsten, Taricano, Flório, et al., 2010)
 DOPAC Adult Female Striatum ↓ (Soto et al., 2013)
 HVA Adult Male Striatum ↓ (Kirsten, Taricano, Flório, et al., 2010)
 HVA Adult Male/Female Hypothalamus ↓ (Kirsten & Bernardi, 2017)
 HVA Adult Female Striatum ↓ (Soto et al., 2013)
Prenatal Poly I:C Exposure
 D1 Receptor Binding Adult Male/Female DS, NAcc Shell ↑ (Vuillermot et al., 2010)
 D1 Receptor Binding Adult Male PFC ↓ (Meyer, Nyffeler, et al., 2008)
 D2 Receptor Binding Adult Male PFC ↓ (Meyer, Nyffeler, et al., 2008)
 D2 Receptor Binding Adult Male/Female Striatum ↓ (Ozawa et al., 2006)
 DA Adult Male/Female Striatum ↑ (Zuckerman, Rehavi, Nachman, & Weiner, 2003)
 DA Fetal and Adult Male/Female SN ↑ (Vuillermot et al., 2010)
 DA Adult Male/Female VTA ↑ (Vuillermot et al., 2010)
 DAT Peripubertal Male/Female DS, NAcc Core, NAcc Shell ↓ (Vuillermot et al., 2010)
 DAT Peripubertal Male/Female NAcc ↓ (Vuillermot et al., 2010)
 DAT Fetal Male/Female VTA, SN ↑ (Meyer, Engler, Weber, Schedlowski, & Feldon, 2008)
 DOPAC Adult Male/Female Striatum ↑ (Ozawa et al., 2006)
 TH Adult Male DS ↑ (Meyer, Nyffeler, et al., 2008)
 TH Fetal Male/Female DS ↑ (Vuillermot et al., 2010)
 TH Peripubertal Male/Female DS, NAcc Core, NAcc Shell ↓ (Vuillermot et al., 2010)
 TH Adult Male/Female NAcc Core, NAcc Shell ↑ (Vuillermot et al., 2010)
 TH Fetal Male/Female VTA, SN ↑ (Meyer, Engler, et al., 2008)

Note. DA = dopamine; MIA = maternal immune activation; ASD = autism spectrum disorder; DAT = dopamine transporter; DOPAC = dihydroxyphenylacetic acid; HVA = homovanillic acid; TH = tyrosine hydroxylase; cerebral cortex; DS = dorsal striatum; NAcc = nucleus accumbens; PFC = prefrontal cortex; SN = substantia nigra; VTA = ventral tegmental area