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. 2019 Mar 5;9:3492. doi: 10.1038/s41598-019-40175-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Protein microarray binding of influenza HA bnAbs. (a–l) Representative ProtoArray summary for protein arrays blotted with (a) FI6, (b) 41-5E04, (c) CR6261, (d) CR9114, (e) MEDI8852, (f) FY1, (g) CH67, (h) K03.12, (i) H2526, (j) CR8033, (k) C05, (l) 6649 or 151 K control. Axis values are relative fluorescence signal intensity (MFI) in the 151 K array (y axis) or test mAb array (x axis). Each dot represents the average of duplicate array proteins. A diagonal line indicates equal binding by test mAb and 151 K. Internal controls for loading of mAb and secondary detection reagent were equally bound by mAb pairs (boxes). Dashed lines indicate the 500-fold signal/background ratio defined as the cutoff for autoreactivity. Circles identify protein autoligands recognized by autoreactive bnAbs.