. Author manuscript; available in PMC: 2020 Mar 1.

Published in final edited form as: Lancet Infect Dis. 2018 Dec 13;19(3):e65–e76. doi: 10.1016/S1473-3099(18)30477-8

Table 2.

Summary of host genetic factors that affect outcome of TB transmission

Chromosome	Gene	TST/IGRA	Resistance/Susceptibility	Possible Mechanism
2 and 5	IL10 haplotype	TST	Resistance	Unresolved⁸²
2 and 5	IL10 haplotype	TST	Resistance	Low circulating IL10⁸³
11p14	TST1	TST	Resistance	Controls lack of TST response^84,85
5p15	TST2	TST	Resistance	Controls extent of TST response⁸⁴
6p25	DRB1/DQA1	TST	Susceptibility	TST-positivity¹⁴⁴
11p14	TNF1	TST	Resistance?	Controls TNF production upon exposure to BCG⁸⁶
	ULK1	TST	Susceptibility	Role in TNF production⁸⁸
	TOLLIP	TST	Susceptibility	Role in TNF production⁸⁷
	IL9	TST	Resistance	Mast cells⁸⁹
8q12-q22		IGRA	Resistance	IFNᵧ production on BCG exposure⁹⁰
3q 13-q22		IGRA	Resistance?	IFNᵧ production on BCG and ESAT-6 exposure⁹⁰
3q 13-q22	ZXDC	IGRA	Resistance?	IFNᵧ release in response to ESAT-6⁹¹