Table 3:

Risk factors for acute and chronic GVHD

Acute GvHD		N	N-event	sHR (95% CI)	p
	Total	404	95
Registry	EBMT	229	36
	CIBMTR	175	59	2.39 (1.55 – 3.67)	<0.001
Age	50–64	337	71
	>=65	67	24	1.7 (1.07 – 2.72)	0.026
Patient sex	Male	208	52
	Female	196	43	0.86 (0.56 – 1.32)	0.49
Performance score	<90%	180	41
	90–100%	224	54	1.2 (0.78 – 1.85)	0.41
GvHD prophylaxis	CNI + MMF	96	32
	CNI + MTX	210	47	0.69 (0.43 – 1.11)	0.13
	Other	98	16	0.54 (0.29 – 1.01)	0.054
Regimen	non-TBI regimen	303	62
	TBI regimen	101	33	0.96 (0.55 – 1.67)	0.87
Donor	Identical sibling	209	35
	Unrelated donor	195	60	2.01 (1.18 – 3.42)	0.011
Graft source	Bone marrow	220	53
	Peripheral blood	184	42	0.94 (0.62 – 1.42)	0.78
Interval diag-Tx (yrs)		404		1.06 (1 – 1.12)	0.033
Chronic GvHD		N	N-event	sHR (95% CI)	p
	Total	315	98
Registry	EBMT	143	38
	CIBMTR	172	60	1.3 (0.85 – 2.01)	0.23
Age	50–64	261	77
	>=65	54	21	1.2 (0.74 – 1.97)	0.46
Patient sex	Male	155	54
	Female	160	44	0.84 (0.56 – 1.26)	0.4
Performance score	<90%	142	42
	90–100%	173	56	1.11 (0.72 – 1.7)	0.64
GvHD prophylaxis	CNI + MMF	76	38
	CNI + MTX	166	48	0.52 (0.33 – 0.81)	0.004
	Other	73	12	0.27 (0.14 – 0.53)	<0.001
Regimen	non-TBI regimen	229	70
	TBI regimen	86	28	0.94 (0.51 – 1.75)	0.85
Donor	Identical sibling	158	47
	Unrelated donor	157	51	1.11 (0.65 – 1.88)	0.71
Graft source	Bone marrow	179	49
	Peripheral blood	136	49	1.31 (0.85 – 2)	0.22
Interval diag-Tx (yrs)		315		1.03 (0.96 – 1.1)	0.46