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. 2019 Feb 27;10:317. doi: 10.3389/fimmu.2019.00317

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Copyright © 2019 Liu, Zhou, Wu, Hu, Yang, Li, Wu, Chen, Chen, Lin, Cui, Fu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combination therapy of CT26 tumor with H-RT and L-TBI. (A) CT26-derived tumors model and treatment timeline. Immunocompetent mice were injected s.c. with syngeneic CT26 cells (2.5 × 10⁴) into the right (primary tumor) and left (secondary tumor) flank, respectively. Only the primary tumor received H-RT (n = 12 mice/group). CT26 tumor growth curves of primary irradiated tumors (B) and secondary non-irradiated tumors (C) between different groups (n = 8 mice/group). (D) Overall survival curves of investigation groups (n = 8 mice/group). (^*P < 0.05, ^**P < 0.01, ^***P < 0.001, and NS = not significant).