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. 2019 Jan 30;9(4):1096–1114. doi: 10.7150/thno.29673

Figure 4.

Figure 4

HDAC4 and HIF-1α are key molecules in p53 and RAS signaling networks. A. Gene expression profiles of p53 and RAS signaling cascades. Red and green represent upregulated and downregulated genes, respectively. B-C. HDAC4 (B) and HIF-1α (C) mRNA levels determined by q-PCR in SKOV3T and SKOV3T/V12 cells. D. Effects of p53 and RAS mutants on the expression and acetylation ability of HDAC4 and pHDAC4. E. Expression of HIF-1α under normoxia and hypoxia in the presence or absence of p53 and/or RAS mutants. F-G. Altered expression of HDAC4, pHDAC4 and HIF-1α induced by inhibition of ERK (F) and AKT (G). Protein markers are properly labeled in relative panels.