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. 2019 Jan 30;9(4):1170–1180. doi: 10.7150/thno.26281

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© Ivyspring International Publisher

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RPE-specific deletion of TSC1 leads to choroidal pathology. (A) The eyecups of RPE/choroid from 3- to 12-month-old RPE-TSC1^-/- mice exhibited progressive choroidal thinning (light area; white arrows). (B) The images of DIC captured from 3-to 12-month-old RPE-TSC1^-/- mice showed abnormal melanosome distribution. Scale bar: 100 μm. (C- D) The morphology of retina/RPE choroid and sclera of 5-month-old (C) or 10-month-old (D) RPE-TSC1^-/- mice and controls are shown. Scale bar: 50 μm. Choroid thickness was statistically analyzed. ONH, optic nerve head (n = 3, *P<0.05, ** P<0.01). INL: inner nuclear layer.