Skip to main content
. 2019 Jan 30;9(4):1066–1084. doi: 10.7150/thno.29754

Figure 5.

Figure 5

Promotion of pro-angiogenic factors in plasma-treated wounds. (A) SKH1 mice were either exposed to plasma for 3 s or 20 s or were left untreated (ctrl). The mRNA level of CD31 was strongly increased on day 15 (**p< 0.01). Both the basic FGF (bFGF) and KGF (FGF7) were significantly upregulated in the plasma-treated animals at all time points. Cyclooxygenase (COX2) and VE-cadherin (CDH5) were only regulated on day 15 in the plasma-treated groups. (B) Immunohistological staining confirmed a stronger expression of CD31 (arrowhead) and KGF (asterisks) after 6 days in plasma-treated animals compared to controls. Scale bar is 50 µm. (C) KGF protein expression showed a significant increase on day 6 whereas Akt and phospho-Akt proteins were up-regulated in plasma-treated females. Males and females were used at on 15 (as indicated, (n > 8).); on d3/d6 only females were available for the measurements (n > 3). The data are presented as mean +/- S.D.; *p<0.05, **p<0.01, ***p< 0.001, as compared to controls (ctrl) at each day and assay.