TABLE 2.

Contribution of Nef-mediated HLA downregulation, baseline plasma viral load, cART timing, and HIV subtype on log₁₀ proviral DNA levels at 48 weeks post-cART: final multivariable model

Variable	Final model
	Estimatea	P value
Nef-mediated HLA downregulation	NDd	NDd
Very early cARTb (MAA+c)	−0.32	0.066
Baseline log10 plasma viral load	0.30	0.011
HIV subtype B infection	0.98	0.00001

^aβ estimates are expressed as follows: Nef-mediated HLA downregulation (per percent function increment) and baseline plasma viral load (per log₁₀ increment). For the timing of cART initiation, participants who started cART later than 141 days postinfection (MAA⁻) are the reference group. For HIV subtype, non-subtype B-infected participants were the reference group. The adjusted R² value was 0.65, and P was 1.1 × 10⁻⁶.

^bcART, combination antiretroviral therapy.

^cMAA⁺, multiassay algorithm positive (participants who started cART within 141 days after infection).

^dNA, not applicable; variable was not selected in the final multivariable model.