TABLE 3.

Model 1: contribution of Nef-mediated HLA downregulation, baseline plasma viral load, baseline CD4 T-cell count, and cART timing on log₁₀ proviral DNA levels at 48 weeks post-cART

Variable	Final model
	Estimatea	P value
Nef-mediated HLA-I downregulation	0.006	0.11
Baseline CD4+ T cell count	−0.0006	0.14
Very early cARTb (MAA+c )	−0.25	0.13
Baseline log10 plasma viral load	0.19	0.10

^aβ estimates are expressed as follows: Nef-mediated HLA downregulation (per percent function increment), baseline plasma viral load (per log₁₀ increment), and baseline CD4⁺ T cell count (per cell per cubic millimeter increment). For the timing of cART initiation, participants who started cART later than 141 days postinfection (MAA⁻) were the reference group. The adjusted R² value was 0.54, and P was 4.4 × 10⁻⁴.

^bcART, combination antiretroviral therapy.

^cMAA⁺, multiassay algorithm positive (participants who started cART within 141 days after infection).