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Alignment of the gp41 HR1 regions of the 40 env sequences from historical (HP), intermediate (IP), and contemporary (CP) patients with the HXB2 reference sequence. Identical residues are represented by dots. Residues G36, I37, V38, Q39, Q40, N42, and N43, whose mutations G36D/S, I37V, V38A/M/E, Q39R, Q40H, N42T, and N43D, respectively, have been shown to be associated with resistance to enfuvirtide, are highlighted in yellow.
