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Pathogenicity in vivo of FILORAB3. (A) Survival in newborn BALB/c mice (n = 8) intracranially challenged with escalating doses of live FILORAB3 compared to live parental rabies virus (BNSP). (B) Survival in adult SCID mice (n = 8) challenged intramuscularly with 6 log10 FFU of either FILORAB3, BNSP as a positive control, or PBS as a negative control. The log-rank (Mantel-Cox) test was used for comparison of survival curves to assess significant differences in survival.
