Skip to main content
. 2019 Mar 5;93(6):e02011-18. doi: 10.1128/JVI.02011-18

FIG 4.

FIG 4

The sialic acid specificity of viruses is dependent on the amino acid at position 226 in glycan array assays. The receptor-binding specificity of a subset of mutant viruses in the H9N2 backbone was determined using a glycan array. L, Q, M, F, I, S, H, N, V, C, T, and G correspond to amino acid mutations at position 226 in the HA of H9N2 viruses. Glycans on the array comprise nonsialoside controls (glycans 1 to 10; gray), α2-3 sialosides (glycans 11 to 79; yellow), and α2-6 sialosides (glycans 80 to 135; green). Glycans are grouped by structure type: L, linear; O, O linked; N, N linked; and Lx, sialyl-Lewis X. RFU, relative fluorescent units. Plotted data represent means ± standard errors (SEM).