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. 2019 Feb 26;10:344. doi: 10.3389/fmicb.2019.00344

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Copyright © 2019 Wu, Wang, Wang, Wu, Chen, Li, Cheng and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRIM14 PRYSPRY domain promotes the degradation of NP. (A–D) Immunoblot analysis of extracts of HEK293T (A), TRIM14^-/- HEK293T (B), IFNAR1^-/- HEK293T (C) or TBK1^-/- HEK293T (D) cells co-transfected with RNP reconstitution system and TRIM14 or TRIM14 mutants. The relative quantifications of NP were shown in Supplementary Figures S3A–D. (E–J) Immunoblot analysis of extracts of HEK293T cells co-transfected with Flag-NP (200 ng) and increasing amounts (0 ng, 200 ng, 400 ng) of HA-TRIM14 (E), HA-S1 (F), HA-S2 (G), HA-ΔB (H), HA-BCC (I), and HA-ΔS2 (J). The relative quantifications of NP were shown in Supplementary Figures S3E–J.