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. 2019 Mar 5;10(2):e02567-18. doi: 10.1128/mBio.02567-18

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Copyright © 2019 Cabrera et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 6 — IFNs decrease Vps4A and Vps4B mRNA levels in TG mouse neurons. (A) mRNA levels of Vps4A, Vps4B, Chmp4B, Chmp2B, and Isg15 were analyzed by qPCR using TG mRNA from infected LC3-GFP^+/− mice during the indicated times. Quantification of Sybr Green signal was normalized to β-actin; n = 5 for all genes analyzed and all time points, except for Chmp2B Mock (n = 3). All samples were performed with two technical replicates. *, P < 0.05; **, P < 0.01; ***, P < 0.001. (B) mRNA levels of Vps4A, Vps4B, and Isg15 were analyzed by qPCR using TG primary neurons from LC3-GFP^+/− mice treated with IFN β+γ during indicated times. Quantification of Sybr Green signal was normalized to β-actin; n = 6 for all genes analyzed and all time points. All samples were performed with two technical replicates. *, P < 0.05; **, P < 0.01; ***, P < 0.001.