Table 2.

Test performance of single markers and marker combinations

		Training set		Validation set
Marker	Cut-off	Sensitivity (%)	Specificity (%)	Sensitivity (%)	Specificity (%)
CA19-9 (≥ 55 U/ml)
		55	91	63	96
THBS2 (≥ 42 ng/ml)
		41	96	50	96
cfDNA (ng/ml)
5 FP	12.4	86	70	80	79
4 FP	16.0	68	87	70	96
3 FP	16.2	68	87	70	96
2 FP	18.8	65	65	57	96
1 FP	19.0	45	91	57	96
0 FP	28.0	32	100	43	96
CA19-9 (≥ 55 U/ml) + THBS2 (≥ 42 ng/ml)
		73	91	80	96
CA19-9 (≥ 55 U/ml) + THBS2 (≥ 42 ng/ml) + cfDNA (ng/ml)
5 FP	12.4	86	78	93	92
4 FP	16.0	86	83	87	92
3 FP	16.2	86	87	87	92
2 FP	18.8	73	91	80	92
1 FP	19.0	73	96	80	92
0 FP	28.0	41	96	50	96

FP=false-positives