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. 2019 Mar 5;8(3):285–297. doi: 10.1002/open.201900011

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© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Concentration‐response curves of 1, 2 and 3 (black), as well as 116, 120, 124, 129, 133, 143 and 144 (colored) at the gpH₂R (atrium). Histamine (1) was used as a reference (pEC₅₀=6.16, E_max=1.00). Displayed curves are calculated by endpoint determination (N=1).