Fig. 10. Schematic diagram of malfunction of glymphatic and meningeal lymphatic drainage post SAH. (A) Under intact conditions, perivascular AQP4 mediates convective flow from para-arterial to para-venous spaces, thus facilitating drainage of brain macromolecular substances to the dcLNs via meningeal lymphatic vessels. (B) After SAH, blood clots block the meningeal lymphatic drainage route, resulting in blood cells and components entering into and accumulating within brain perivascular spaces. This in turn impairs glymphatic clearance function, causing accumulation of toxic metabolites and immune components within the brain parenchyma as well as long-term brain damage.
