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. 2019 Feb 22;10:268. doi: 10.3389/fmicb.2019.00268

FIGURE 7.

FIGURE 7

Two-way ANOVA of genera with relative abundances greater than 2% from the phyla Proteobacteria, Bacteroidetes, and Deferribacteres in the colonic mucosa of the TLR4-/- and WT mice fed the VAN or VAD diet. The combined effects of the different VA nutritional levels and TLR4 deletion on the relative abundance of (A) Alistipes and (B) Rikenellaceae_RC9 (n = 10). The main effect of VA, independent of TLR4 deletion, on the relative abundance of (C) Parasutterella and (F) Mucispirillum in the four groups (n = 10). The main effect of TLR4, independent of VA levels, on the relative abundance of (D) Bacteroides and (E) Alloprevotella among the four groups (n = 10). Mean ± SEM; ns. = not significant. “Interaction” indicates an effect of the different VA nutritional levels in the TLR4 knockout vs. WT mice; ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. VAN, vitamin A normal; VAD, vitamin A deficiency. WT VAN refers to WT mice fed a VAN diet; WT VAD refers to WT mice fed a VAD diet; KO VAN refers to TLR4-/- mice fed a VAN diet; KO VAD refers to TLR4-/- mice fed a VAD diet.