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. 2019 Feb 25;10:273. doi: 10.3389/fimmu.2019.00273

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Copyright © 2019 Blaurock-Möller, Gröger, Siwczak, Dinger, Schmerler, Mosig and Kiehntopf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Release of cytokines and adhesion molecules in the liver-on-chip model stimulated with CAAP48. (A) Cytokine concentrations of IL-1β, IL-6, TNFα, and IL-10 within the supernatants of the vascular layer were determined by flow cytometry using a bead-based multiplex immunoassay. (B) The release of sVCAM-1 and sICAM-1 within the supernatants of the vascular layer were examined by Bio-Plex assay. Results of six independent experiments are shown.