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. 2019 Feb 20;13:110. doi: 10.3389/fnins.2019.00110

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Copyright © 2019 Chang, Kwon, Bang, Kim, Baek, Ryu, Bae, Fan, Lee, Kim, Lee, Yang and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of preinjection of collagenase or bupivacaine into acupoints in various animal models. (A–C) Effect of pretreatment of type I collagenase or bupivacaine in HT7 acupoint on cocaine-induced locomotor activity in rats. Inhibition of cocaine-induced locomotion by acupuncture at HT7 (Acup) was prevented by pretreatment of bupivacaine (BUPIVA) into HT7 acupoint (A), but not type I collagenase (COLG; B,C). ^*p < 0.05 vs. Normal; ^#p < 0.05 vs. Control; ^$p < 0.05 vs. BUPIVA+Acup; n = 5 per group. Representative tracings (B). (D–F) Effect of pretreatment of type I collagenase or bupivacaine in the PC6 acupoint on immobilization-induced hypertension in rats. Bupivacaine, but not collagenase, inhibited the acupuncture effects of PC6 (D) on elevated systolic blood pressure in rats (E,F) Representative pulse signals measured from tail (E) ^*p < 0.05 vs. Control (immobilization only without acupuncture); ^#p < 0.05 vs. BUPIVA+Acup; n = 5 per group. (G–I) Effect of pretreatment of type I collagenase or bupivacaine in acupoints on mustard oil-induced visceral pain in rats. Electromyogram (EMG) in each group was recorded during colorectal distension of 20, 40, 60, and 80 mmHg for approximately 5 s. Normal, normal rats; Control, mustard only without acupuncture; Acup, acupuncture in mustard-treated rats; COLG+Acup, pretreatment of collagenase prior to acupuncture in mustard-treated rats; BUPIVA+Acup, pretreatment of bupivacaine prior to acupuncture in mustard-treated rats. n = 7 per group. Acupoints used. (G) Representative EMG signals recorded during colorectal distension of 80 mmHg (H). Bupivacaine, but not collagenase, inhibited the acupuncture effects on colorectal distension-induced visceral motor responses in rats (I). ^*p < 0.05 vs. Normal; ^#p < 0.05 vs. Control; ^$p < 0.05 vs. BUPIVA+Acup; n = 7 per group. Acup, acupuncture; COLG, collagenase; BUPIVA, bupivacaine.