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. 2019 Feb 26;10:153. doi: 10.3389/fphys.2019.00153

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Copyright © 2019 Dong, Zhang, Wen, Chen, He, Wang, Yin, Wu, Xue, Li, Fan and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A long ischemia duration induced AKI-to-CKD transition in IRI mice. (A) HE and Masson staining of kidneys during the chronic phase of kidney injury (original magnification × 400; Scale bar, 20 μm). (B) Tubulointerstitial fibrosis scores of mouse kidneys during the chronic phase of kidney injury. (C) Changes in Scr levels in mice in 28 days post ischemia. Data are presented as the means ± SEM of four experiments. n = 6; ^∗P < 0.05 vs. the control group. #P < 0.05 vs. the 20 min-ischemia group. ΦP < 0.05 vs. the 30 min-ischemia group.