Table 1.

Clinical studies examining the efficacy of antidepressant medications in children and adolescents.

Age (years)	SSRI	Dose and duration	Outcome	Reference
13–18	Citalopram	10 mg/day12 weeks	No difference from placebo	von Knorring et al., 2006
7–17	Citalopram	20–40 mg/day8 weeks	Improved treatment compared to placebo	Wagner et al., 2004
7–17	Duloxetine	60–120 mg/day36 weeks	No difference from placebo	Atkinson et al., 2014
7–17	Duloxetine	30, 60, 90, or 120 mg/day36 weeks	No difference from placebo	Emslie et al., 2014
12–17	Escitalopram	10 or 20 mg/day8 weeks	Improved treatment compared to placebo	Emslie et al., 2009
12–17	Escitalopram	10–20 mg/day24 weeks	Improved treatment compared to placebo	Findling et al., 2013
6–17	Escitalopram	10–20 mg/day8 weeks	No difference from placebo	Wagner et al., 2006
7–17	Fluoxetine	20 mg/day8 weeks	Improved treatment compared to placebo	Emslie et al., 1997
8–18	Fluoxetine	10 or 20 mg/day9 weeks	Improved treatment compared to placebo	Emslie et al., 2002
12–17	Fluoxetine	10–40 mg/day12 weeks	Improved treatment compared to placebo	March et al., 2004
13–18	Fluoxetine	20, 40, or 60 mg/day7 weeks	No difference from placebo	Simeon et al., 1990
13–18	Paroxetine	20–40 mg/day12 weeks	No difference from placebo	Berard et al., 2006
7–17	Paroxetine	10–50 mg/day8 weeks	No difference from placebo	Emslie et al., 2006
12–18	Paroxetine	20–40 mg/day8 weeks	Improved treatment compared to placebo	Keller et al., 2001
6–17	Sertraline	50–200 mg/day6 weeks	Improved treatment compared to placebo	Alderman et al., 1998
6–17	Sertraline	50–200 mg/day10 weeks	Improved treatment compared to placebo	Wagner et al., 2003
12–17	Vilazodone	15 or 30 mg/day8 weeks	No difference from placebo	Durgam et al., 2018