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. 2019 Feb 25;9:94. doi: 10.3389/fonc.2019.00094

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Copyright © 2019 Zannini, Rustighi, Campaner and Del Sal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PIN1 is involved in sensing and transducing metabolic cues. (Upper part) Different nutritional and hormonal stimuli impinge on PIN1 levels and activity, which is necessary for the proper activation of metabolic pathways. (Lower part) Absence of PIN1 in unicellular organisms or metazoans causes lethality or metabolic alterations as shown for yeast and mice, respectively. Upregulation of PIN1 in human cancers supports the Warburg effect. Blue color indicates PIN1-activated proteins, red color indicates PIN1-inhibited proteins.