Figure 3.

Overview of the major metabolic pathways in Dendritic cells. Cellular metabolic processes provide DCs with the necessary energy to sustain their immunological functions. In a resting state, DCs rely on oxidative phosphorylation to meet their bioenergetic requirements. When faced with pathogens, DCs undergo metabolic reprogramming skewed toward aerobic glycolysis for ATP generation, and the establishment of pro-inflammatory responses. Of note, different reports seem to suggest that HIF1a play a dual role in metabolic reprogramming in leishmaniasis. It has been shown that L. donovani infection enhances the stabilization of HIF1a, which in turn leads to decreased Il-12 production. Conversely, It has been demonstrated that HIF1a increases nitric oxide production, which subsequently results in L. major elimination.