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. 2019 Feb 19;10:167. doi: 10.3389/fpls.2019.00167

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Copyright © 2019 Catalá, Carrasco-López, Perea-Resa, Hernández-Verdeja and Salinas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative model for the function of LSM2-8 complex in U6 snRNA maturation, formation of the di- and tri-snRNPs, and splicesome regeneration. After its transcription by the Pol III, the U6 snRNA is stabilized by the binding of the La protein to its oligo-U tract. The binding to the body of the snRNA of Prp24 and the excision of the last U by MPN1/USB1/UBL1 (MPN1) promote the substitution of MPN1 by the LSM2-8 complex. The U6 snRNA, Prp24 and the LSM2-8 complex constitute the U6 snRNP that, subsequently, favors the formation of U4/U6 di- and U4/U6.U5 tri-snRNPs. In addition, after the splicing reaction a fully functional LSM2-8 complex is essential for the regeneration of the spliceosome.