Table 4.
Examples of implantable drug delivery devices for pain management, infectious disease and central nervous system disorders. ND = Not disclosed.
| Therapeutic Indication | Product Name | Implant Type | Material | Drug Delivered | Indication | References |
|---|---|---|---|---|---|---|
| Pain | ND (Axxia Pharmaceuticals) |
Sub-cutaneous | PU, PEG/PPG/PTMEG | Hydromorphine | Chronic neuropathic pain | [141] |
| LiRIS® | Intra-vesical | Silicone | Lidocaine | Interstitial cystitis/bladder pain syndrome | [142,143] | |
| Probuphine® | Sub-cutaneous | PEVA | Buprenorphine | Opioid abuse | [144] | |
| Infectious Diseases | ND | ND | PLGA | Isoniazid | TB | [145] |
| ND | ND | PLGA | Isoniazid, Pyrazinamide | TB | [146] | |
| Central Nervous System disorders | Med-Launch | Sub-cutaneous | PLGA | Risperidone | Schizophrenia | [8,147] |
| ND | Sub-cutaneous | PU | Risperidone | Schizophrenia | [148] | |
| Risperdal consta® | Intra-muscular | PLGA | Risperidone | Schizophrenia | [149] |