Table 1.
Qualitative and quantitative composition of the optimized minocycline hydrochloride (MH)-loaded starch-stabilized pickering emulsions (MHASt-emulsions).
| Formulations | Quantitative Composition (%, w/w) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ASt-Emulsion with Liquid Paraffin (LP) | ASt-Emulsion with Caprylic/Capric Acid Triglyceride (CT) | MHASt-Emulsion with LP | MHASt-Emulsion with CT | |||||||||
| 2.5% | 5% | 7.5% | 2.5% | 5% | 7.5% | 2.5% | 5% | 7.5% | 2.5% | 5% | 7.5% | |
| Phase A (external) | ||||||||||||
| Liquid paraffin | 72.50 | 70.00 | 67.50 | - | - | - | 72.45 | 69.95 | 67.45 | - | - | - |
| Caprylic/capric acid triglyceride | - | - | - | 72.50 | 70.00 | 67.50 | - | - | - | 72.45 | 69.95 | 67.45 |
| Phase B (solid particles) | ||||||||||||
| Aluminum starch octenylsuccinate | 2.50 | 5.00 | 7.50 | 2.50 | 5.00 | 7.50 | 2.50 | 5.00 | 7.50 | 2.50 | 5.00 | 7.50 |
| Phase C (internal) | ||||||||||||
| Purified water | 25.00 | 25.00 | 25.00 | 25.00 | 25.00 | 25.00 | 25.00 | 25.00 | 25.00 | 25.00 | 25.00 | 25.00 |
| Minocycline hydrochloride | - | - | - | - | - | - | 0.05 | 0.05 | 0.05 | 0.05 | 0.05 | 0.05 |