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. 2019 Mar 5;14:8. doi: 10.1186/s13027-019-0224-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Representative case data.

a Computed tomographic examination of the neck. The thyroid cartilage is invaded by LC. b Surgical specimen of the larynx. A large transglottic tumor is noted. c–g Histology results of the primary LC lesion. Hematoxylin-eosin staining at low (c, bar = 100 μm) and high magnification (d, bar = 50 μm); p16 immunohistochemical staining (e, bar = 50 μm); DNA in situ hybridization (ISH) (f, bar = 50 μm); RNA ISH (g, bar = 20 μm). (h) p16 immunohistochemical staining in a metastatic lymph node (bar = 100 μm).