Table 1.

Objectives of the IMPROVE feasibility trial

Primary	Secondary
1. Feasibility of recruitment strategy for local health service and participants	1. Estimates of effect size and variability to enable accurate sample size and power calculations for a definitive RCT
2. Time necessary to recruit participants	2. Identification of any differences across age groups and other socio-demographic factors with regards to attrition rate
3. Acceptability of the study design and random allocation	3. Identification of key barriers and enablers to adoption, and large-scale implementation, of the IMPROVE trial are
4. What the most appropriate inclusion/exclusion criteria are	4. Definition of required for economic analysis and if they can be collected reliably
5. Estimates of compliance, satisfaction, follow- up and attrition rates	5. The capacity of the research team to embed this study into routine practice in the Public Health Centres
	6. To determine the initial effects of the intervention, time and intervention-time interaction on inflammatory biomarkers concentrations and periodontitis status