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. 2019 Mar 5;19:227. doi: 10.1186/s12879-019-3833-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — PCV13 Trial Simulated in 3 + 1 Vaccinated Population. a VT carriage prevalence in all four trial arms. Lines represent average VT prevalence across 50 simulations while shading is bounded by one standard deviation. b The difference in VT prevalence between the 3 + 1 and 2 + 1 trial arms (averaged across 50 simulations) graphed over time. c The difference in VT prevalence between the 3 + 1 and 1 + 1 trial arms (averaged across 50 simulations) graphed over time. The zero difference line is shown in red. Note the scale of the y-axis