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. 2019 Mar 5;19:227. doi: 10.1186/s12879-019-3833-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Relative Vaccine Efficacies in a Simulated PCV13 Trial. a Relative VE determined using prevalences. b Relative VE determined using prevalence odds. In both sub-figures, the “calculated” relative VE was determined from the initial VE parameters of the simulation according to the formula: Relative VE = 1 – (1 – VE_intervention)/(1 – VE_reference)