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. 2019 Mar 6;20:175. doi: 10.1186/s12864-019-5514-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — Phylogenetic tree analysis of the family-A (rhodopsin-like) GPCRs discovered in the transcriptomes from T. cystophora and A. alata. The tree has been rooted with the Drosophila mGlu receptor CG2114. The opsins are highlighted in blue. The LGRs are highlighted in orange. When, during a TBLASTN search, the receptor was computer-identified as a neuropeptide GPCR, the cubomedusan GPCR was highlighted in yellow in this figure. Computer-identification as a biogenic amine GPCR let us to highlight these receptors in green. It can be seen that the computer-identified neuropeptide and biogenic amine GPCRs do not form two discrete clusters and, therefore, it is difficult to conclude that a certain receptor is a neuropeptide or biogenic amine receptor. See also Additional file 9 for GenBank Data Bank accession numbers