Table 3.
The effect of CD13 silencing on the IC50 values and RIs for MKN45/X cells after treatment with chemotherapeutic drugs for 24 h.
| Drugs | MKN45 IC50 (ug/ml) |
MKN45/X + pTZU6+1 |
MKN45/X+ pTZU-CD13-shRNA | ||
|---|---|---|---|---|---|
| IC50(ug/ml) | RI | IC50(ug/ml) | RI | ||
| 5-fluorouracil | 20.54±0.02 | 147.91±0.02 | 7.20±0.01 | 80.24±0.1∗∗ | 3.90±0.2∗ |
|
| |||||
| Cisplatin | 0.41±0.01 | 8.30±0.02 | 20.05±0.02 | 3.13±0.1∗∗ | 7.63±0.1∗∗ |
|
| |||||
| Oxaliplatin | 18.94±0.01 | 125.72±0.01 | 6.63±0.01 | 70.23±0.1∗∗ | 3.73±0.1∗ |
IC50 values and RIs were determined by the CCK-8 method. Data are expressed as means ± SD from three independent experiments. ∗P<0.05 and ∗∗P<0.01 versus 5-fluorouracil, cisplatin, and oxaliplatin without pTZU-CD13-shRNA transfection.