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. 2019 Feb 13;7:88–96. doi: 10.1016/j.pvr.2019.02.002

Fig. 6.

Fig. 6

Schematic representation of viral translocations and sites of viral integration into the host genome. (A) Linearized CPV16 genome including location of genes. The gray bar indicates the deleted portion of the CPV16 genome within the sample of squamous cell carcinoma (SCC). The deleted portion spans the E1 and E2/E4 genes. (B) Linearized CPV16 genome as predicated within the host genome. The inset on the left shows the results of 2 different amplicons identified with genome walking. The first includes a translocation (indicated by a blue rectangle) of a portion of the viral long control region (LCR) to the E2/E4 gene. The second identified the L2 gene integrated into canine chromosome 18. The inset on right shows 4 different amplicons identified with genome walking, including a translocation of a portion of the E1 gene (indicated by red rectangle); a translocation followed by integration into canine chromosome 7; integration of the E1 gene into chromosome 16; and integration of the E1 gene into chromosome 3.