Table 2.

Collagen Genes with Relatively High Expression in Skin

		Average Normalized RPKMa		Fold Difference
		Humans	NH Great Apesb
(a) Genes encoding proteins that form collagens in the epidermal BM zone
COL4A1	Collagen type IV alpha 1 chain	54.6	21.5	2.5
COL4A2	Collagen type IV alpha 2 chain	77.5	32.9	2.4
COL7A1	Collagen type VII alpha 1 chain	32.9	16.8	2.0
COL17A1	Collagen type XVII alpha 1 chain	181.7	76.4	2.4*
COL18A1	Collagen type XVIII alpha 1 chain	41.7	18.3	2.3***
(b) Genes encoding proteins that form BGN-binding collagens
COL1A1	Collagen type I alpha 1 chain	444.4	198.5	2.2
COL1A2	Collagen type I alpha 2 chain	311.3	134.9	2.3
COL3A1	Collagen type III alpha 1 chain	404.7	148.9	2.7
COL6A1	Collagen type VI alpha 1 chain	276.3	106.2	2.6
COL6A2	Collagen type VI alpha 2 chain	459.3	185.1	2.5**
COL6A3	Collagen type VI alpha 3 chain	45.6	27.3	1.7

^aIn mapping to the human reference genome.

^bNH great apes: nonhuman great apes.

^*P < 0.05,

^**P < 0.01, and

^***P < 0.001, t-test with Bonferroni correction.