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3D structures for two MHC class I molecules with bound peptides longer than 9 amino acids (PDB references 2CLR and 4JQX). (a) The 10mer peptide MLLSVPLLLG bound to HLA-A*02:01 extends at the C terminus with a glycine (G) amino acid. The residues at the anchor positions P2 (L) and P9 (L) are highlighted. (b) The 12mer EECDSELEIKRY bound to HLA-B*44:03 has anchors at its second (E) and last (Y) positions and bulges out from the middle of the MHC binding groove
