Skip to main content
. Author manuscript; available in PMC: 2019 Mar 6.
Published in final edited form as: Annu Rev Immunol. 2013 Dec 18;32:83–119. doi: 10.1146/annurev-immunol-032713-120249

Fig. 2. Summary of the putative substrates of PTPN22 in T cells.

Fig. 2.

Established substrates include Y420 and Y394 in activation loops of Src family kinases Fyn(18) and Lck(36] respectively, and the autoactivatory Y493 of Zap-70){Wu, 2006 #35). Putative PTPN22 substrates that undergo tyrosine phosphorylation upon TCR engagement include i) TCR-CD3ζ and CD3ε, ii) the guanine nucleotide exchange factor Vav, iii) the ATPase valosin containing protein (VCP)(11). Y75 of Src-kinase associated protein homolog (SKAP-HOM) is a recently-described T cell substrate for PTPN22(31).