Figure 1.

Brain tumors harbor abnormal vasculatures and extracellular matrix. a) Compared to normal brain blood vessels, tumor vessels are chaotic, heterogeneous, and irregular. The morphologically abnormal blood vessels are b) more leaky, due to increased vascular permeability. PS = permeability surface‐area product, n = 5. c) Furthermore, compared to normal brain tissues, brain tumors are densely packed with collagen. d) The significantly increased collagen content within the tumor, combined with elevated interstitial fluid pressure and cellular mass, compresses intratumoral vessels, leading to e) blood flow stasis. * denotes p < 0.05; error bars = mean ± standard deviation. Scale bars = 100 µm.