Figure 2.

DC101 treatment normalizes tumor vasculature and improved vessel functions. a) Schematics demonstrate the treatment schedule for DC101 and anti‐TGFβ. b) Intravital microscopy revealed that DC101 normalizes blood vessels in orthotopically implanted GL261 glioma as compared to iso‐matched IgG control. Green = GFP labeled tumor cells. Red = DsRed‐dextran labeled tumor vasculatures. c) DC101 treatment resulted in morphological normalization of tumor vessels as measured by decreases in vessel tortuosity and density as early as 5 days after treatment initiation. d) The normalized tumor vessels also exhibit more mature phenotype as demonstrated by increased pericyte coverage (NG2⁺CD31⁺/CD31⁺), leading to a decrease of vascular leakage and e) permeability. * denotes p < 0.05; error bars = mean ± standard deviation; n = 7. PS: permeability surface‐area product. Scale bars = 100 µm.