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. 2019 Jan 15;6(5):1801809. doi: 10.1002/advs.201801809

Figure 1.

Figure 1

Schematic illustration of the preparation of vitamin A–decorated pH‐sensitive and SPIO‐loaded nanoplex T‐PBP@miRNA/SPIO (T‐miRNA/S) for miRNA targeting delivery, resulting in synergistically downregulated expression of liver fibrosis–related genes for alleviating liver fibrosis. The red arrows indicate the reduction of COL1A1, TIMP1, and collagen fiber. Abbreviations: COL1A1, collagen type I alpha 1 protein; TIMP1, tissue inhibitor of metalloproteinase 1; SPIO, superparamagnetic iron oxide.