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. 2019 Jan 15;6(5):1801809. doi: 10.1002/advs.201801809

Figure 2.

Figure 2

Synthesis and characterization of the polymer and nanoplexes. A) Synthetic route of the triblock copolymer VA–PEG–bPEI–PAsp(DIP–BzA) denoted as T‐PBP. B) 1H NMR spectrum of the T‐PBP polymer. C) Particle size and zeta potential of SPIO‐loaded nanoplex (T‐SCR/S) with different N/P ratios at pH 7.4. Data are shown as mean ± SD, n = 3. TEM images of T‐SCR/S (N/P 10) at D) pH 7.4 and E) pH 5.0. F) Electrophoretic mobility of SCR in agarose gel after complexation with SPIO‐free micelle (N‐SCR and T‐SCR) and SPIO‐loaded micelle (T‐SCR/S) at various N/P ratios. Abbreviations: SCR, scrambled miRNA; N‐SCR, nontargeting PBP micelle complexing SCR; T‐SCR, targeting T‐PBP micelle complexing SCR; T‐SCR/S, T‐PBP micelle complexing SCR and encapsulating SPIO.