Skip to main content
. 2019 Apr;95(4):337–348. doi: 10.1124/mol.118.114348

Fig. 2.

Fig. 2.

Evaluation of protective effects of HYP9 and compound 64402 in conditions of amyloid synaptotoxicity. (A) Representative confocal images of day 14 of in vitro cultivation hippocampal neurons transfected with tdTomato plasmid. Images for control (CTRL) cultures and cultures exposed to oligomeric Aβ42 are shown as indicated. HPF was added at the concentration of 300 nM, HYP9 was tested at concentrations of 100 nM and 1 µM as indicated, compound 64402 was tested at the 1 µM concentration. (B) The average percentages of mushroom spines (%MS) in each experimental condition are present as mean ± S.D. (n ≥ 16 neurons for each group). Untreated hippocampal cultures (CTRL) are shown as the filled bar. Open bars correspond to hippocampal cultures that were treated with oligomeric Aβ42. *P < 0.05; ***P < 0.0005 by one-way ANOVA, following Dunn-Sidak post hoc test.